In the new millennium, competence of many organizations will depend on innovative deployment of new technologies for effectively managing knowledge networks for organizational performance. Some “virtual” organizations based on information and knowledge as their fundamental bases are redefining the “reality” of the traditional “brick-and-mortar” economy. In the process, they are posing challenges and opportunities by redefining traditional thinking about industries, organizations, competition, products, services, technologies, people and economy. This text provides a compilation of theories, case studies and best practices, information and communication technologies, methodologies, methods and measures that relate to the topics of knowledge management and new organization forms such as virtual organizations.